ir. R.S. Rosendaal
ir. R.S. Rosendaal
- Pulmonology Research 2
- Onderzoek
Research Programs
Biography
Biography
Dr. J.M. Beekman obtained a PhD in molecular immunology in 2004, and performed multiple post docs in molecular and cell biology within various immunological settings. In October 2010, he became principle investigator at the UMC Utrecht, and started a novel translational research line focusing on developing novel therapeutic strategies for cystic fibrosis, a genetic disease characterized by aberrant ion and fluid homeostasis at mucosal surfaces leading to chronic infection and inflammation and early death around the 3rd to 4th decade of life.
‘People with chronic diseases living healthy lives: I strive to create breakthrough solutions for clinical needs of people with chronic diseases by scientific research that focuses on the development of novel diagnostic or therapeutic approaches. This requires a multidisciplinary approach in which basic and clinical research is aligned, and integrated with needs of patients, the private sector and regulatory authorities. Currently, I am particularly proud of leading a team that developed a highly innovative diagnostic assay that enables individualized therapy for people with cystic fibrosis that lead to direct clinical impact for people within 4 years after the initial discovery.’
Side Activities
Professional activities
2021 Co-founder Fair Therapeutics
2020 Member selection committee for “3V-stimuleringsfonds” UU and UMCU
2019 Vice-president organizing committee European CF society conference 2022
2018 PhD Committee and opponent of Franz Shan Brunel, University of Aberdeen, UK
2017 PhD Committee and opponent of Karen Schelde, University of Aarhus, Denmark
2017 Consultant at CFF Theratyping workshop
2016 European CF society basic science working group – vice coordinator
2016 Grant reviewer Canadian Foundation for Innovation
2016 Grant reviewer Cystic Fibrosis Research, Inc. (CFRI)
2016 Grant reviewer German CF society
2016 Advisor for future funding of UK Cystic Fibrosis Trust (Research Sandpit Workshop, 8-9 Feb)
2015 Grant reviewer SRC grant application Cystic Fibrosis Trust (UK)
2015 Avicenna Roadmap Authoring Team – A strategy for in silico clinical trials
2013 – Editorial board member of Rare Diseases
2013 – Editorial board member of PlosOne
2013 – Annual candidate selection committee for Eureka Institute of Translational Medicine
2010 – Reviewer for various journals including Cell, Nature Medicine, Nature Communications, PlosOne, Journal of Immunological Methods, Journal of Leukocyte Biology, Molecular Immunology, Journal of Medical Genetics, Journal of Cystic Fibrosis
Memberships
2019- UWE, collaboration Utrecht-Wageningen-Eindhoven
2019- Membership transition-team for animal-free innovation Utrecht
2014 – European Respiratory Society
2010 – European Cystic Fibrosis Society
2011 – Eureka Institute for Translational Medicine
2000 – Dutch Society of Immunology (NVVI
Potential Conflicts of Interest
Dr Beekman has regular interactions with commercial parties including pharmaceutical companies, and performs academic associated research mostly in public-private partnerships or fee-for-service activities with such companies. Beekman was PI on grants with Galapagos, Proteostasis, and Eloxx Pharmaceuticals that led to major funding contributions from these companies to UMCU (>100K). Other companies provided in kind contributions. He is inventor of a patent (20210333266) that was licensed to Hubrecht Organoid Technology and he received personal royalties from 2017 onward (max annual income <3000 euros up to 2021) from the Royal Dutch Academy of Sciences and Arts. Dr Beekman has received personal support for preparation of meetings or consultancy (all below 2200 euro per event), or reimbursement of traveling and lodging costs for participating in industry-sponsored educational meeting (all below €2200 per event). He co-founded FAIR therapeutics BV in 2021 and has a minority shareholders position.
Research Output (99)
Rümke Lidewij W, Groenveld Femke C, van Os Yvonne M G, Praest Patrique, Tanja Anniek A N, de Jong Dorien T C M, Symons Jori, Schuurman Rob, Reinders Tessa, Hofstra L Marije, Nierkens Stefan, Thijsen Steven F T, Heron Michiel, Lebbink Robert-Jan, Beekman Jeffrey M, Nijhuis Monique, Wensing Annemarie M J Jan 2022, In: Open forum infectious diseases. 9 , p. 1-6
Muilwijk Danya, Bierlaagh Marlou, van Mourik Peter, Kraaijkamp Jasmijn, van der Meer Renske, van den Bor Rutger, Heijerman Harry, Eijkemans René, Beekman Jeffrey, van der Ent Kors 16 Dec 2021, In: Journal of Personalized Medicine. 11 , p. 1-12
Geurts Maarten H., de Poel Eyleen, Pleguezuelos-Manzano Cayetano, Oka Rurika, Carrillo Léo, Andersson-Rolf Amanda, Boretto Matteo, Brunsveld Jesse E., van Boxtel Ruben, Beekman Jeffrey M., Clevers Hans Oct 2021, In: Life Science Alliance. 4
de Poel Eyleen, Spelier Sacha, Korporaal Ricardo, Lai Ka Wai, Boj Sylvia F., Conrath Katja, van der Ent Cornelis K., Beekman Jeffrey M. 15 Sep 2021, In: Frontiers in Molecular Biosciences. 8
Bierlaagh Marlou C., Muilwijk Danya, Beekman Jeffrey M., van der Ent Cornelis K. Sep 2021, In: European Journal of Pediatrics. 180 , p. 2731-2739 9 p.
Jeyaratnam Joshena, van der Meer Renske, Berkers Gitte, Heijerman Harry Gm, Beekman Jeffrey M, van der Ent Cornelis K 23 Jun 2021, In: Journal of Cystic Fibrosis. 20 , p. e63-e66
Berkers Gitte, van der Meer Renske, van Mourik Peter, Vonk Annelotte M, Kruisselbrink Evelien, Suen Sylvia Wf, Heijerman Harry Gm, Majoor Christof J, Koppelman Gerard H, Roukema Jolt, Janssens Hettie M, de Rijke Yolanda B, Kemper E Marleen, Beekman Jeffrey M, van der Ent Cornelis K, de Jonge Hugo R Nov 2020, In: Journal of Cystic Fibrosis. 19 , p. 955-961 7 p.
Van Mourik Peter, van Haaren Paul, Kruisselbrink Evelien, Korkmaz Cemil, Janssens Hettie M., de Winter – de Groot Karin M., van der Ent Cornelis K., Hagemeijer Marne C., Beekman Jeffrey M. Sep 2020, In: Journal of Cystic Fibrosis. 19 , p. 728-732 5 p.
Vonk Annelotte M, van Mourik Peter, Ramalho Anabela S, Silva Iris A L, Statia Marvin, Kruisselbrink Evelien, Suen Sylvia W F, Dekkers Johanna F, Vleggaar Frank P, Houwen Roderick H J, Mullenders Jasper, Boj Sylvia F, Vries Robert, Amaral Margarida D, de Boeck Kris, van der Ent Cornelis K, Beekman Jeffrey M 19 Jun 2020, In: STAR protocols. 1 31 p.
Geurts Maarten H., de Poel Eyleen, Amatngalim Gimano D., Oka Rurika, Meijers Fleur M., Kruisselbrink Evelien, van Mourik Peter, Berkers Gitte, de Winter-de Groot Karin M., Michel Sabine, Muilwijk Danya, Aalbers Bente L., Mullenders Jasper, Boj Sylvia F., Suen Sylvia W.F., Brunsveld Jesse E., Janssens Hettie M., Mall Marcus A., Graeber Simon Y., van Boxtel Ruben, van der Ent Cornelis K., Beekman Jeffrey M., Clevers Hans 2 Apr 2020, In: Cell stem cell. 26 , p. 503-510.e7